The series revolves around best friends Mitchell Taylor and Stanley Hope. Like earlier Eerie, Indiana, residents Marshall Teller and Simon Holmes and they are constantly encountering strange and out-of-this-world phenomena in their hometown. Helping out in their adventures is the mysterious local bartender, Mr. Crawford. The show is technically a spin-off of "Eerie, Indiana" (1991), since it takes place in a parallel universe Eerie that gets "infected" by weirdness when a villain opens a portal from the original Eerie to this one in the first episode of this show.